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We discussed a case of a
young AML patient with PTPN11 mutated (Glu76Lys, missense,
NPM1 neg/ flt3 ITD neg)
In a study (Hou et al, Leukemia volume 22, pages 1075–1078
(2008) (https://doi.org/10.1182/blood-2018-99-110319)
PTPN11 mutations were found in 5.1% adult AML patients and they
were exclusively missense...
According to bibliography, G-CSF administration on day -1, 8 or
during febrile neutropenia is not relevant with the progression of
the disease. In contrast, G-CSF administration reduces TRM and
can accelerate ANC recovery.
As a result, we decided to administer G-CSF from day 15 (from
the...
We presented a retospective analysis of BEAM vs BuCYVP16
in HL.
BEAM conditioning before AHSCT resulted in a statistically
significant
improved PFS and OS and lower relapse when compared with
BUCYVP16.
Patients with shorter remission time from diagnosis and in
non-CR at
time of AHSCT benefited most from...
When, Where, and How to use FLT3 inhibitors?
What is their value? What are the open questions.
Presenter:Prof.Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr
Katsaouni
We discussed an excellent review on mechanisms of relapse
and its
treatment.
- Major mechanisms of relapse include HLA loss, HLA
down-regulation, and expression of
coinhibitory ligands.
- Combination of donor lymphocyte infusion with
immunomodulating agents and tyrosine kinase
inhibitors may enhance the
graft-versus-leukemia (GVL) effect.
- Immune checkpoint inhibitors can induce a...
Στα πλαίσια ενημέρωσης, την Τρίτη 9/4/2019
πραγματοποιήθηκε, στην αίθουσα σεμιναρίων της Παθολογικής κλινικής,
παρουσίαση του φαρμακου Cresemba από εκπροσώπους της εταιρείας
Pfizer.
We discussed current concepts and treatment of HCV.
Presenter: Prof. Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni
We discussed a case for BL/BLL which was referred for
HSCT. We reviewed the literature regarding BL/ BLL/
DLBCL.
In the 2008 revisions to the WHO classification, atypical
BL/BLL is no longer formally recognized; many of these cases
are
now classified as BL, whereas others are...
We presented a case of an isolated myeloid sarcoma and
discussed the
current literature with the specific question of transplant
or not.
Presenter:Prof Spyridonidis
Participants:Dr Liga, Dr Spyridis, Dr Lekka, Dr
Katsaouni
2019-W10:α1-Antitrypsin Infusion for treatment of Steroid Resistant Acute Graft-versus-Host Disease.
Presenter:Prof Spyridonidis
Participants:Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni
We discussed a case of conjuctival MALT lymphoma and
reviewed the
current literature.
Presenter:Prof.Spyridonidis
Participants:Dr Liga, Dr Spyridis, Dr Lekka, Dr
Katsaouni
Presenter:Prof. Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni
Presenter: Prof.Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni
Presenter:Prof.Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni
We discussed 2 interesting papers for mechanisms of relapse
post allogeneic HSCT which can be either HLA-loss, HLA-down
regulation or immune escape.
Presenter: Prof.Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni
Presenter: Prof. Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni
An update on CMV was presented. We discussed the open access
slides of the ECIL 7 consensus on CMV. In addition we discussed the
recently change of the LAb which performs CMV monitoring and the
new reporting (from copies/ml to IU/ml). We discussed...
We discussed the REV infections in HSCT recipients.
Presenter: Prof. Marangos
Participants: Prof. Spyridonidis, Dr Liga, Dr Spyridis, Dr
Lekka, Dr Katsaouni
We presented a study that showed that NGS-based MRD is
widely
applicable to AML patients, is highly predictive of relapse
and
survival, and may help refine transplantation and
posttransplantation
management in AML patients.
Presenter: Prof. Spyridondis
Patricipants: Dr Liga, Dr Spyridis, Dr Lekka, Dr
Bountouris
We presented Treatments that made headlines in hematology
in 2018. From Nature
Medicine 24,1785–1787 (2018)
Presenter: Prof. Spyridonidis
Paricipants: Dr Liga, Dr Spyridis, Dr Lekka, Dr
Bountouris
Green light
CD19 CAR therapy
Chimeric antigen receptor (CAR) therapy using the CD19 antigen
continued to show its benefits after a long-term follow-up study
found that...
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