We discussed an excellent review on mechanisms of relapse and its  treatment. - Major mechanisms of relapse include HLA loss, HLA down-regulation, and  expression of coinhibitory ligands. - Combination of donor lymphocyte infusion with immunomodulating agents and tyrosine kinase inhibitors may enhance the graft-versus-leukemia (GVL) effect. - Immune checkpoint inhibitors can induce a...

Στα πλαίσια ενημέρωσης, την Τρίτη 9/4/2019 πραγματοποιήθηκε, στην αίθουσα σεμιναρίων της Παθολογικής κλινικής, παρουσίαση του φαρμακου Cresemba από εκπροσώπους της εταιρείας Pfizer.    

We discussed current concepts and treatment of HCV. Presenter: Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

We discussed a case for BL/BLL which was referred for HSCT. We reviewed the literature regarding BL/ BLL/ DLBCL. In the 2008 revisions to the WHO classification, atypical BL/BLL is no longer formally recognized; many of these cases are now classified as BL, whereas others are...

We presented a case of an isolated myeloid sarcoma and discussed the  current literature with the specific question of transplant or not. Presenter:Prof Spyridonidis Participants:Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

Presenter:Prof Spyridonidis Participants:Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

We discussed a case of conjuctival MALT lymphoma and reviewed the  current literature.   Presenter:Prof.Spyridonidis Participants:Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

Presenter:Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

Presenter: Prof.Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

Presenter:Prof.Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

We discussed 2 interesting papers for mechanisms of relapse post allogeneic HSCT which can be either HLA-loss, HLA-down regulation or immune escape. Presenter: Prof.Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

Presenter: Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

An update on CMV was presented. We discussed the open access slides of the ECIL 7 consensus on CMV. In addition we discussed the recently change of the LAb which performs CMV monitoring and the new reporting (from copies/ml to IU/ml). We discussed...

We discussed the REV infections in HSCT recipients. Presenter: Prof. Marangos Participants: Prof. Spyridonidis, Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni

We presented a study that showed that NGS-based MRD is widely  applicable to AML patients, is highly predictive of relapse and  survival, and may help refine transplantation and posttransplantation  management in AML patients. Presenter: Prof. Spyridondis Patricipants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris

We presented Treatments that made headlines in hematology in 2018. From  Nature Medicine 24,1785–1787 (2018) Presenter: Prof. Spyridonidis Paricipants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris   Green light CD19 CAR therapy Chimeric antigen receptor (CAR) therapy using the CD19 antigen continued to show its benefits after a long-term follow-up study found that...

Early-Stage Follicular Lymphoma: What Is the Preferred Treatment  Strategy  in Early-Stage Follicular Lymphoma? WW, RT, Chemo,  Immunoterpay or a combination of the above? Porobaly lla are the saem  iof one consideres OS as outocem,but may differ in regard to EFS.   A critical opinion on a randomized study...

A Japanese study questioned the "favorable" status of AML with low  allelic ratio FLT3-ITD and NPM1 mutation given by ELN criteria. Flt3 mut  presence is a clear indication for AML. Presenter:Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris