We discussed a case for BL/BLL which was referred for HSCT. We reviewed the literature regarding BL/ BLL/ DLBCL.

In the 2008 revisions to the WHO classification, atypical BL/BLL is no longer formally recognized; many of these cases are
now classified as BL, whereas others are relegated to the provisional category of unclassifiable B-cell lymphoma with features intermediate between DLBCL and BL. This category has been created to encompass the cases likely to truly represent the continuum between these two subtypes of mature B-cell NHL. This heterogeneous group includes the worst prognostic category, “dual-hit” mature B-cell NHL, which manifests both MYC and BCL2 gene rearrangements, resulting in an extremely aggressive clinical course and universally poor outcome despite treatment with intensive chemoimmunotherapy regimens. 

Presenter: Dr Liga
Participants: Proof. Spyridonidis, Dr Spyridis, Dr Lekka, Dr Katsaouni