Καταχωρήθηκε: Παρασκευή 07 Ιαν 2022
Mantle cell lymphoma (MCL) is a subtype of B cell non-Hodgkin lymphoma characterized by a heterogeneous clinical presentation. Patients who demonstrate an objective response to induction therapy(ies) and are eligible for intensive therapies are offered an autologous hematopoietic cell transplant (HCT) as front-line consolidation followed by rituximab maintenance. Allogeneic HCT is an option for younger and fit patients with high-risk disease or in patients who have relapsed after autologous HCT. Recent advances in T cell engineering brought chimeric antigen receptor T cell (CAR T) therapy from the bench to the bedside, with brexucabtagene autoleucel being the first CAR T product approved by the US Food and Drug Administration for use in relapsed/refractory MCL. In this comprehensive review, we summarize the literature on available cellular therapies for MCL and present a treatment algorithm that incorporates HCT, autologous or allogeneic, and CAR T therapies.


  • High-risk features predict for inferior response to conventional chemoimmunotherapy.
  • Autologous hematopoietic cell transplant is offered as front-line consolidation.
  • Allogeneic hematopoietic cell transplant is a potentially curative option.
  • Brexucabtagene autoleucel shows remarkable efficacy in relapsed/refractory disease.
Presenter: Prof Spyridonidis
Participants: Dr Liga, Dr Tsokanas

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