Λίστα αντικειμένων
Duration of shedding of viable SARS-CoV-2 in severely immunosuppressed patients with cancer
For most patients with COVID-19, persistently positive nucleic acid
testing after symptom resolution does not indicate prolonged
infectiousness. However, accumulating evidence suggests that some
severely immunocompromised patients may have prolonged shedding of
viable SARS-CoV-2. One study of 20 patients with a hematologic
malignancy and COVID-19, 18 of whom had hematopoietic cell
transplantation or CAR T cell therapy and two with lymphoma, found that
viable virus could be grown in culture from respiratory samples for up
to two months after symptom onset. The best way to determine duration of
isolation for severely immunocompromised patients who have persistently
positive nucleic acid testing is uncertain. In some cases, information
about the cycle threshold (Ct) may be incorporated.
REF: Aydillo T, Gonzalez-Reiche AS, Aslam S, et al. Shedding of Viable
SARS-CoV-2 after Immunosuppressive Therapy for Cancer. N Engl J Med
2020.
Presenter: Prof.Spyridonidis
Participants: Dr Liga, Dr Tsokanas, Dr Lekka
For most patients with COVID-19, persistently positive nucleic acid
testing after symptom resolution does not indicate prolonged
infectiousness. However, accumulating evidence suggests that some
severely immunocompromised patients may have prolonged shedding of
viable SARS-CoV-2. One study of 20 patients with a hematologic
malignancy and COVID-19, 18 of whom had hematopoietic cell
transplantation or CAR T cell therapy and two with lymphoma, found that
viable virus could be grown in culture from respiratory samples for up
to two months after symptom onset. The best way to determine duration of
isolation for severely immunocompromised patients who have persistently
positive nucleic acid testing is uncertain. In some cases, information
about the cycle threshold (Ct) may be incorporated.
REF: Aydillo T, Gonzalez-Reiche AS, Aslam S, et al. Shedding of Viable
SARS-CoV-2 after Immunosuppressive Therapy for Cancer. N Engl J Med
2020.
Presenter: Prof.Spyridonidis
Participants: Dr Liga, Dr Tsokanas, Dr Lekka