Λίστα αντικειμένων
We discussed an excellent review on mechanisms of relapse and its
treatment.
- Major mechanisms of relapse include HLA loss, HLA down-regulation, and expression of coinhibitory ligands.
- Combination of donor lymphocyte infusion with immunomodulating agents and tyrosine kinase inhibitors may enhance the graft-versus-leukemia (GVL) effect.
- Immune checkpoint inhibitors can induce a significant GVL effect, but
toxicity is high.
Presenter:Prof. Spyridonidis
Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Katsaouni